Publications

Degree of immobilization of synthetic RGDS(PO3H2)PA peptides on titanium surfaces
Y. Abe, Y. Okazaki, K. Hiasa, I. Hirata, Y. Yoshida, T. Taji, K. Suzuki, M. Okazaki, Y. Akagawa
Dent. Mater. J. 29:668‒672 (2010)

Chemical analyses of hydroxyapatite formation on SAM surfaces modified with COOH, NH2, CH3, and OH functions
I. Hirata, M. Akamatsu, E. Fujii, S. Poolthong, M. Okazaki
Dent. Mater. J. 29:438‒445 (2010)

2009

Hyaluronic acid hydrogel loaded with genetically-engineered brain-derived neurotrophic factor as a neural cell carrier
T. Nakaji-Hirabayashi, K. Kato, H. Iwata
Biomaterials 30:4581–4589 (2009)

Enhanced survival of neural cells embedded in hydrogels composed of collagen and laminin-derived cell adhesive peptide
M. Hiraoka, K. Kato, T. Nakaji-Hirabayashi, H. Iwata
Bioconjugate Chem. 20:976–983 (2009)

Surface-displayed antibodies as a tool for simultaneously controlling the arrangement and morphology of multiple cell types with microscale precision
H. Miyazaki, T. Maki, K. Kato, H. Iwata
ACS Appl. Mater. Interfaces 1:53–55 (2009)

Surface-anchoring of spontaneously dimerized epidermal growth factor for highly selective expansion of neural stem cells
T. Nakaji-Hirabayashi, K. Kato, H. Iwata
Bioconjugate Chem. 20:102–110 (2009)

Prolonged durability of electroporation microarrays as a result of addition of saccharides to nucleic acids
H. Fujimoto, K. Kato, H. Iwata
Anal. Bioanal. Chem. 393:607–614 (2009)

Bone formation ability of carbonate apatite-collagen scaffolds with different carbonate contents

A. Matsuura, T. Kubo, K. Doi, K. Hayashi, K. Morita, R. Yokota, H. Hayashi, I. Hirata, M. Okazaki, Y. Akagawa

Dent. Mater. J. 28:234‒242 (2009)

2008

Electroporation microarray for parallel transfer of small interfering RNA into mammalian cells
H. Fujimoto, K. Kato, H. Iwata
Anal. Bioanal. Chem. 392:1309–1316 (2008)

Essential role of structural integrity and firm attachment of surface-anchored epidermal growth factor in adherent culture of neural stem cells
T. Nakaji-Hirabayashi, K. Kato, H. Iwata
Biomaterials 29:4403–4408 (2008)

A collagen-binding mimetic of neural cell adhesion molecule
H. Miyazaki, K. Kato, Y. Teramura, H. Iwata
Bioconjugate Chem. 19:1119–1123 (2008)

Self-assembling chimeric protein for the construction of biodegradable hydrogels capable of interaction with integrins expressed on neural stem/progenitor cells
T. Nakaji-Hirabayashi, K. Kato, H. Iwata
Biomacromolecules 9:1411–1416 (2008)

Multifunctional chimeric proteins for the sequential regulation of neural stem cell differentiation
T. Nakaji-Hirabayashi, K. Kato, Y. Arima, H. Iwata
Bioconjugate Chem. 19:516–524 (2008)

Use of microarrays in transfection of mammalian cells with dicer-digested small interfering RNAs
H. Fujimoto, K. Kato, H. Iwata
Anal. Biochem. 374:417–422 (2008)

High-throughput cytometry using antibody arrays

K. Kato, I.-K. Ko, T. Ishimuro, M. Toda, Y. Arima, I. Hirata, H. Iwata

Biomaterials in Asia T. Tateishi, ed., 2008, World Scientific Publishing Co Pte Ltd., Singapore, pp. 506–516

Higher concentrations of fluoride ions dramatically inhibit the survival of osteoblasts
I. Hirata, M. Okazaki
J. Oral Tissue Eng. 6:3‒8 (2008)

Influence of chlorine dioxide on cell death and cell cycle of human gingival fibroblasts
R. Nishikiori, Y. Nomura, M. Sawajiri, K. Masuki, I. Hirata, M. Okazaki
J. Dent. 36:993‒998 (2008)

Influence of the chemical structure of functional monomers on their adhesive performance
K. L. Van Landuyt, Y. Yoshida, I. Hirata, J. Snauwaert, J. de Munck, M. Okazaki, K. Suzuki, P. Lambrechts, B. Van Meerbeek
J. Dent. Res. 87:757‒761 (2008)

Complement activation on surfaces carrying amino groups
M. Toda, T. Kitazawa, I. Hirata, Y. Hirano, H. Iwata
Biomaterials 29:407‒417 (2008)

2007

High-throughput immunophenotyping by surface plasmon resonance imaging
K. Kato, T. Ishimuro, I. Hirata, Y. Arima, H. Iwata
Anal. Chem. 79:8616–8623 (2007)

Ultrastructural study on the specific binding of genetically engineered epidermal growth factor to type I collagen fibrils
K. Kato, H. Sato, H. Iwata
Bioconjugate Chem. 18:2137–2143 (2007)

Array-based functional screening for genes that regulate vascular endothelial differentiation of Flk1-positive progenitors derived from embryonic stem cells
F. Yamauchi, M. Okada, K. Kato, J. L. Martin, H. Iwata
Biochim. Biophys. Acta, General Subjects 1770:1085–1097 (2007)

Oriented immobilization of epidermal growth factor onto culture substrates for the selective expansion of neural stem cells
T. Nakaji-Hirabayashi, K. Kato, Y. Arima, H. Iwata
Biomaterials 28:3517–3529 (2007)

Antibody arrays for quantitative immunophenotyping
K. Kato, M. Toda, H. Iwata
Biomaterials 28:1289–1297 (2007)

Combinatorial protein display for the cell-based screening of biomaterials that direct neural stem cell differentiation
M. Nakajima, T. Ishimuro, K. Kato, I.-K. Ko, I. Hirata, Y. Arima, H. Iwata
Biomaterials 28:1048–1060 (2007)

Apoptotic and necrotic influence of dental resin polymerization initiators in human gingival fibroblast cultures
K. Masuki, Y. Nomura, U. Kumar B., M. Sawajiri, I. Hirata, Y. Nahara, M. Okazaki
Dent. Mater. J. 26:861‒869 (2007)

Cell adhesion and proliferation patterns on mixed self-assembled monolayers carrying various ratios of hydroxyl and methyl groups
Y. Fuse, I. Hirata, H. Kurihara, M. Okazaki
Dent. Mater. J. 26:814‒819 (2007)

Acceleration of bone formation with BMP2 in frame-reinforced CO3Ap-collagen sponge scaffolds
I. Hirata, Y. Nomura, M. Ito, A. Shimazu, M. Okazaki
J. Artif. Organs 10:212‒217 (2007)

Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials
Y. Hamada, H. Egusa, Y. Kaneda, I. Hirata, N. Kawaguchi, T. Hirao, T. Matsumoto, M. Yao, K. Daito, M. Suzuki, H. Yatani, M. Daito, M. Okazaki, N. Matsuura
Dent. Mater. J. 26:487‒492 (2007)

Immobilization of simulated reducing agent at the surface of SiO2 fillers in dental composite resins
S. Shibata, I. Hirata, Y. Nomura, K. Shirai, M. Fujitani, H. Shintani, M. Okazaki
Dent. Mater. J. 26:568‒574 (2007)

2006

Fabrication of cell-based microarrays using micropatterned alkanethiol monolayers for the parallel silencing of specific genes by small-interfering RNA
H. Fujimoto, S. Yoshizako, K. Kato, H. Iwata
Bioconjugate Chem. 17:1404–1410 (2006)

Layer-by-layer assembly of cationic lipid and plasmid DNA onto gold surface for stent-assisted gene transfer
F. Yamauchi, Y. Koyamatsu, K. Kato, H. Iwata
Biomaterials 27:3497–3504 (2006)

Analysis of chemical interaction of 4-MET with hydroxyapatite using XPS
K. Nagakane, Y. Yoshida, I. Hirata, R. Fukuda, Y. Nakayama, K. Shirai, T. Ogawa, K. Suzuki, B. Van Meerbeek, M. Okazaki
Dent. Mater. J. 25:645‒649 (2006)

Detailed consideration of physicochemical properties of CO3 apatites as biomaterials in relation to carbonate content using ICP, X-ray, diffraction, FT-IR, SEM, and HR-TEM
R. Yokota, H. Hayashi, I. Hirata, Y. Miake, T. Yanagisawa, M. Okazaki
Dent. Mater. J. 25:597‒603 (2006)

Development of surface plasmon resonance imaging apparatus for high-throughput study of protein-surface interactions
Y. Arima, R. Ishii, I. Hirata, H. Iwata
e-J. Surf. Sci. Nanotech. 4:201‒207 (2006)

2005

A thin carboxymethyl cellulose culture substrate for the cellulase-induced harvesting of an endothelial cell sheet
I.-K. Ko, K. Kato, H. Iwata
J. Biomater. Sci. Polym. Ed. 16:1277–1292 (2005)

Layer-by-layer assembly of poly(ethyleneimine) and plasmid DNA onto transparent indium-tin oxide electrodes for temporally- and spatially-specific gene transfer
F. Yamauchi, K. Kato, H. Iwata
Langmuir 21:8360–8367 (2005)

Immobilization of histidine-tagged recombinant proteins onto micropatterned surfaces for cell-based functional assays
K. Kato, H. Sato, H. Iwata
Langmuir 21:7071–7075 (2005)

Parallel analysis of multiple surface markers expressed on rat neural stem cells using antibody microarrays
I.-K. Ko, K. Kato, H. Iwata
Biomaterials 26:4882–4891 (2005)

Antibody microarray for correlating cell phenotype with surface marker
I.-K. Ko, K. Kato, H. Iwata
Biomaterials 26:687–696 (2005)

Advantages of TOF-SIMS analysis of hydroxyapatite and fluorapatite in comparison with XRD, HR-TEM and FT-IR
M. Okazaki, I. Hirata, T. Matsumoto, J. Takahashi
Dent. Mater. J. 24:508‒514 (2005)

SEM observation of collagen fibrils secreted from the body surface of osteoblasts on a CO3apatite-collagen sponge
I. Hirata, Y. Nomura, H. Tabata, Y. Miake, T. Yanagisawa, M. Okazaki
Dent. Mater. J. 24:460‒464 (2005)

2004

Synthesis and characterization of stimuli-sensitive hydrogels having a different length of ethylene glycol chains carrying phosphate groups: loading and release of lysozyme
K. Nakamae, T. Nishino, K. Kato, T. Miyata, A. S. Hoffman
J. Biomater. Sci. Polym. Ed. 15:1435–1446 (2004)

Spatially and temporally controlled electroporation of adherent cells on plasmid DNA-loaded electrode
F. Yamauchi, K. Kato, H. Iwata
Nucleic Acids Res. 32:e187 (2004)

Drug permeation through temperature-sensitive microfiltration membranes prepared from poly(vinylidene fluoride) with grafted poly(N-isopropylacrylamide) side chains
L. Ying, E.T. Kang, K.G. Neoh, K. Kato, H. Iwata
J. Membr. Sci. 243:253–262 (2004)

Adsorption of enantiomeric poly(lactide)s on surface-grafted poly(L-lactide)
O. N. Tretinnikov, K. Kato, H. Iwata
Langmuir 20:6748–6753 (2004)

Micropatterned, self-assembled monolayers for fabrication of transfected cell microarrays
F. Yamauchi, K. Kato, H. Iwata
Biochim. Biophys. Acta, General Subjects 1672:138–147 (2004)

Self-assembled monolayers

K. Kato

Encyclopedia of Biomater. Biomed. Eng. 2004, Marcel Dekker, Inc., New York, NY, U.S.A., pp. 1331–1339

Simple method for preparation of ultra-thin poly(N-isopropylacrylamide) hydrogel layers and characterization of their thermo-responsive properties
I. Hirata, M. Okazaki, H. Iwata
Polymer 45:5569‒5578 (2004)

Osteoblast proliferation behavior and bone formation on and in CO3apatite-collagen sponges with a porous hydroxyapatite frame
Y. Tieliewuhan, I. Hirata, A. Sasaki, H. Minagi, M. Okazaki
Dent. Mater. J. 23:258‒264 (2004)

Characterization of CO3Ap-collagen sponges using X-ray high-resolution microtomography
M. Itoh, A. Shimazu, I. Hirata, Y. Yoshida, H. Shintani, M. Okazaki
Biomaterials 25:2577‒2583 (2004)

2003

Polymer surface with graft chains

K. Kato, E. Uchida, E. T. Kang, Y. Uyama, Y. Ikada

Prog. Polym. Sci. 28:209–259 (2003)

Deposition of complement protein, C3b, on mixed self-assembled monolayers carrying surface hydroxyl and methyl groups studied by surface plasmon resonance
I. Hirata, Y. Murakami, E. Kitano, H. Kitamura, Y. Ikada, H. Iwata
J. Biomed. Mater. Res. 66A:669‒676 (2003)

Investigation on light-addressable potentiometric sensor as a possible cell-semiconductor hybrid
A. B. Ismail, T. Yoshinobu, H. Iwasaki, H. Sugihara, T. Yukimasa, I. Hirata, H. Iwata
Biosens. Bioelectron. 18:1509‒1514 (2003)

2002

Hydroxyapatite deposition onto polymer surfaces

K. Kato, O. N. Tretinnikov, Y. Ikada

Biomimetic Calcium Phosphate Coatings H.B. Wen ed., 2002, Research Signpost, Trivandrum, India, pp. 15–29

2001

The interplay between surface micro-topography and -mechanics of type I collagen fibrils in air and aqueous media: An atomic force microscopy study
K. Kato, G. Bar, H.-J. Cantow
Eur. Phys. J. E 6:7–14 (2001)

Glistening formation in an AcrySof lens initiated by spinodal decomposition of the polymer network by temperature change
K. Kato, M. Nishida, H. Yamane, K. Nakamae, Y. Tagami, K. Tetsumoto
J. Cataract Refract. Surg. 27:1493–1498 (2001)

Synthesis of bioadhesive hydrogels from chitin derivatives
X. Zhao, K. Kato, Y. Fukumoto, K. Nakamae
Int. J. Adhesion Adhesives 21:227–232 (2001)

2000

Optical and atomic force microscopy of an explanted AcrySof intraocular lens with glistenings
M. Dogru, K. Tetsumoto, Y. Tagami, K. Kato, K. Nakamae
J. Cataract Refract. Surg. 26:571–575 (2000)

Collagen immobilization onto the surface of artificial hair for improving the tissue adhesion
K. Kato, Y. Kikumura, M. Yamamoto, N. Tomita, S. Yamada, Y. Ikada
J. Adhes. Sci. Technol. 14:635–650 (2000)

Surface modification of Si3N4coated silicon plate for investigation of living cells
I. Hirata, H. Iwata, A. B. Ismail, H. Iwasaki, T. Yukimasa, H. Sugihara
Jpn. J. Appl. Phys. 39, 6441‒6442 (2000)

Study of complement activation on welldefined surfaces using surface plasmon resonance
I. Hirata, Y. Morimoto, Y. Murakami, H. Iwata, E. Kitano, H. Kitamura, Y. Ikada
Colloids Surf. B: Biointerf. 18:285‒292 (2000)

Hydrophilic modification of a polyimide film surface
B. Zhu, H. Iwata, I. Hirata, Y. Ikada
J. Adhes. Sci. Technol. 14:351‒361 (2000)

1999

Preparation of DNA-immobilized immunoadsorbents for treatment of systemic lupus erythematosus
B. Zhu, H. Iwata, D. Kang, Y. Yu, K. Kato, Y. Ikada
J. Biomater. Sci. Polym. Ed. 10:341–350 (1999)

Surface oxidation of cellulose fibers by vacuum ultraviolet irradiation
K. Kato, V. N. Vasilets, M. N. Fursa, M. Meguro, Y. Ikada, K. Nakamae
J. Polym. Sci.: Part A: Polym. Chem. 37:357–361 (1999)

1998

Lysozyme loading and release from hydrogels carrying pendant phosphate groups
K. Nakamae, T. Nizuka, T. Miyata, M. Furukawa, T. Nishino, K. Kato, T. Inoue, A. S. Hoffman, Y. Kanzaki
J. Biomater. Sci. Polymer Ed. 9:43–53 (1998)

Surface modification of polymers by grafting

Y. Uyama, K. Kato, Y. Ikada

Adv. Polym. Sci. 137:1–39 (1998)

Atomic force microscopic analysis of a porous membrane with pHsensitive molecular valves
H. Iwata, I. Hirata, Y. Ikada
Macromolecules 31:3671‒3678 (1998)

Photolysis of a fluorinated polymer film by vacuum ultraviolet radiation
V. N. Vasilets, I. Hirata, H. Iwata, Y. Ikada
J. Polym. Sci., Part A: Polym. Chem. 36:2215‒2222 (1998)

1997

Histologic and mechanical evaluation for bone bonding of polymer surfaces grafted with a phosphate-containing polymer
S. Kamei, N. Tomita, S. Tamai, K. Kato, Y. Ikada
J. Biomed. Mater. Res. 37:384–393 (1997)

In situ hydroxyapatite crystallization for the formation of hydroxyapatite / polymer composites
K. Kato, Y. Eika, Y. Ikada
J. Mater. Sci. 32:5533–5543 (1997)

Ultrastructure of the interface between cultured osteoblasts and surface-modified polymer substrates
M. Yamamoto, K. Kato, Y. Ikada
J. Biomed. Mater. Res. 37:29–36 (1997)

Studies on tumor-promoting activity of polyethylene: Inhibitory activity of metabolic cooperation on polyethylene surfaces is markedly decreased by surface modification with collagen but not with RGDS peptide
R. Nakaoka, T. Tsuchiya, K. Kato, Y. Ikada, A. Nakamura
J. Biomed. Mater. Res. 35:391–397 (1997)

Polymeric supports for immunoadsorption

K. Kato, Y. Ikada

Recent Res. Devel. in Macromol. Res. 2:157–173 (1997)

Atomic force microscopic images of solvated polymer brushes

H. Iwata, I. Hirata, Y. Ikada

Langmuir 13:3063‒3066 (1997)

1996

Effect of the structure of bone morphogenetic protein carriers on ectopic bone regeneration
M. Yamamoto, K. Kato, Y. Ikada
Tissue Eng. 2:315–326 (1996)

Deposition of a hydroxyapatite thin layer onto a polymer surface carrying grafted phosphate polymer chains
K. Kato, Y. Eika, Y. Ikada
J. Biomed. Mater. Res. 32:687–691 (1996)

Surface modification and functionalization of polytetrafluoroethylene films
E. T. Kang, K. L. Tan, K. Kato, Y. Uyama, Y. Ikada
Macromolecules 29:6872–6879 (1996)

Plasma treatment of polyaniline films: Effect on the intrinsic oxidation states
E. T. Kang, K. Kato, Y. Uyama, Y. Ikada
J. Mater. Res. 11:1570–1573 (1996)

XPS Characterization of surface functionalized electroactive polymers
F. C. Loh, K. L. Tan, E. T. Kang, K. Kato, Y. Uyama, Y. Ikada
Surf. Interface Anal. 24:597–604 (1996)

Immobilization of DNA onto a polymer support and its potentiality as immunoadsorbent
K. Kato, Y. Ikada
Biotechnol. Bioeng. 51:581–590 (1996)

1995

Surface graft polymerization of glycidyl methacrylate onto polyethylene and the adhesion with epoxy resin
J. Zhang, K. Kato, Y. Uyama, Y. Ikada
J. Polym. Sci.: Part A: Polym. Chem. 33:2629–2638 (1995)

Selective adsorption of proteins to their ligands covalently immobilized onto microfibers
K. Kato, Y. Ikada
Biotechnol. Bioeng. 47:557–566 (1995)

Protein adsorption onto ionic surfaces
K. Kato, S. Sano, Y. Ikada
Colloids Surf. B: Biointerfaces 4:221–230 (1995)

Peroxide generation and decomposition on polymer surface
E. A. Kulik, M. I. Ivanchenko, K. Kato, S. Sano, Y. Ikada
J. Polym. Sci.: Part A: Polym. Chem. 33:323–330 (1995)

1994

In vitro hydroxyapatite deposition onto a film surface-grafted with organophosphate polymer
O. N. Tretinnikov, K. Kato, Y. Ikada
J. Biomed. Mater. Res. 28:1365–1373 (1994)

1993

Introduction of functional groups onto the surface of polyethylene for protein immobilization
S. Sano, K. Kato, Y. Ikada
Biomaterials 14:817–822 (1993)

Trypsin immobilization on to polymer surface through grafted layer and its reaction with inhibitors
E. A. Kulik, K. Kato, M. I. Ivanchenko, Y. Ikada
Biomaterials 14:763–769 (1993)

EGF-His_Langmuir

Biomaterials 2008

Biomaterials 2007

Biomaterials 2013

Sci Rep 2020

Biotechnol Bioeng 2020

Bioconjug Chem 2009

Biomaterials 2011

Biomaterials 2007_2

ACS AMI 2015

Biomaterials 2005-1

iPS_Komura_2015

NSC in collagen_2

NSC in collagen_1

Array based screen_2011

Egawa

Artificial lymphoid

BDNF

ACS Appl Mater Interf 2009

siRNA_1

Multifunctional chimeras_2008

Keratin

siRNA_2

Anal Chem 2007

FLK-1_Yamauchi

Au NP on collagen

Combinatorial_Nakajima

Biomaterias 2005_2

Electroporation

Department of Biomaterials

Graduate School of Biomedical and Health Sciences, Hiroshima University

Publications